Two down on their luck jazz musicians find themselves out of a job and on the run after the police raid the speakeasy they perform in and they inadvertently stumble upon a gang war. With no money and nowhere to hide, a gig with Sweet Sue and her Society Syncopators at a Florida beach resort seems like the perfect getaway. There's just one problem: the Syncopators are an all-female band, and Joe and Jerry aren't women - yet.
Armed with some dodgy wigs and wobbly falsettos, Joe and Jerry manage to join the Syncopators, where they meet Sugar Kane: a hooch-swilling, ukulele-playing knockout with a soft spot for badboy saxophone players. Barely able to believe their good fortune, things start to go off the rails for the pair when they begin to attract unwanted attention from lecherous millionaires and some familiar faces show up at their hotel for a gathering of the country's most dangerous criminals.