Terrifying odyssey of 1,000 doomed passengers trapped aboard a plague-infested train. Fleeing from the police, a disease ridden terrorist boards the Geneva to Stockholm Express and exposes its passengers to the deadly virus. Colonel MacKenzie (Burt Lancaster) is called in to handle the situation and finds Dr Jonathan Chamberlain (Richard Harris) on board the train. But Chamberlain and his wife (Sophia Loren), are unable to get the sick man into a hovering helicopter and he dies. MacKenzie decides to re-route the train via the Cassandra Crossing - where it will plunge into oblivion. Events take a surprising turn as passengers, heading for certain death, begin to recover. Chamberlain races against time to disconnect the cars.